Custom Viral Vector Development
Gene therapy is a promising new technique for treating cancer and genetic disorders by introducing foreign genomic materials into host cells to elicit a therapeutic benefit. The key to success of gene therapy is to create safe and efficient gene delivery vehicles. Viral vehicles are the most commonly used carriers for delivering DNA because of their high efficiency and safety. Creative Biolabs provides comprehensive viral vectors and cutting-edge viral vector technology for basic research and preclinical applications, including the design and construction of suitable viral vectors and small to large-scale production of viral vectors.

Delivery Potential of Viral Vectors
Viral vectors not only have the ability to effectively infect cells, but also transfer DNA to the host without causing an immune response. Viral vectors are designed to be safe by making them incapable of replication. Genes transferred by viral vectors have dominated the clinical trials in gene therapy because they are more efficient and specific than physical and chemical methods. Viral vectors can be divided into two types: Integrating and non-integrating viral vectors. Integrated viral vectors can be integrated into the human genome, including lentiviral, adeno-associated virus and retroviral vectors; non-integrating vectors, like adenoviral vectors, remain in the nucleus without being integrated into the chromosomal DNA, thus the transgene is apt to lose during cell division and the expression of foreign genes is transient.